CHANGING THE WAY DRUGS ARE DELIVERED
Efficient and effective drug delivery systems are vital in drug development. Our cutting-edge microencapsulation technology for timed and targeted drug delivery allows for lower dosages, reduced side effects, and improved treatment results.

We provide lab-to-market services to pharmaceutical companies to satisfy the demand for novel drug delivery systems, and innovative and efficient treatments.

CREATE SMART DRUGS WITH OUR CONTROLLED-RELEASE MICROCAPSULES

The success of drug therapies is largely influenced by the use of drug delivery systems that are adequate and efficient. Our microencapsulation technology offers great potential for the pharmaceutical industry. In addition to overcoming some of the problems of conventional therapy, our advanced microencapsulation technology enhances therapeutic drug efficacy by introducing timed and targeted drug release.

 

Slow-release drugs are not new to the market. But we are moving a step forward. We are pioneering programmed-shell microcapsules with a controlled release function, a new way to deliver drugs. We optimise the efficiency of existing drugs by using innovative and high-performing drug delivery systems.

 

Possessing unique microencapsulation capabilities, we can precisely programme the release time of drugs, achieving efficacy at an entirely different level. Our advanced microencapsulation technology is the only one on the market which produces programmed-shell microcapsules that can release drugs according to predefined scenarios:

 

Our advanced microencapsulation technology is the only one on the market which produces programmed-shell microcapsules with a complex shell design that can open and release active substances according to predefined scenarios:

  • TIMED RELEASE

    We programme the microcapsules’ shells to release active substances with high precision (release at a specific time of the day).

  • PROLONGED RELEASE

    We can programme the microcapsules’ shells to ensure the constant and prolonged release of active compounds over a long period of time, up to several months.

  • SLOW/FAST RELEASE

    Active substances can be released slowly or immediately.

  • TRIGGERED RELEASE

    Active compounds are released under certain circumstances (release on demand). The microcapsule opening can be triggered by environmental conditions (change in temperature or pH), mechanical action (friction and other forces) or external stimuli (ultrasound, UV light).

     

The time and targeted release functions result in improved efficacy of the drug, prolonged action, and optimal dosage.

 

Controlled drug release is a reliable means to deliver drugs to the target site in a sustained controlled release manner to obtain optimum benefits and maintain the desired concentration without side effects. We deliver drugs into the body at the right time, at the right dosage and at the right place.

 

Microencapsulation is a useful tool to reduce off-target effects that can lead to side effects ranging in severity from mild to life-threatening. Drugs can also be delivered in smaller dosages due to less drug waste on incorrect targets.

 

Today, different methods have been applied for drug delivery. However, the widespread emulsion spray-drying and microemulsification techniques produce emulsion microdroplets with no shells, meaning they are not microcapsules. The lack of shells makes the controlled and timed release impossible. The emulsification process also limits the selection of active substances. While liposomes and microfluidic solutions are more advanced options, liposomes are highly unstable and expensive, and microfluidics is a costly technique and low yield, making it limited mainly to research purposes.

NO LIMITATION FOR ACTIVE SUBSTANCES

We can encapsulate practically any active substance, liquid or solid, including small molecules and microelements.

 

 

 

 

FDA-APPROVED BIOCOMPATIBLE AND BIODEGRADABLE POLYMERS

We can choose from a wide range of FDA-approved biocompatible and biodegradable polymers. Our microcapsules can satisfy the specific needs of vegetarians and vegans.

 

HIGH STABILITY

Unlike liposomes and emulsion droplets, our microcapsules are highly stable, making our technology suitable for a wide range of applications.

 

 

 

 

 

HIGH LOADING CAPACITY

Our microcapsules can hold high volumes of ingredients (cargo-shell ratio up to 10:1).

 

 

 

 

 

 

 

TARGETED DELIVERY OF ANTICANCER DRUGS TO TUMOURS

Our advanced microencapsulation technology has great potential for target delivery of anticancer drugs to tumours.

 

Vincristine, an anticancer drug, is known for its increased cellular toxicity, which results in multiple side effects. The targeted delivery of vincristine and other chemotherapeutic drugs to tumours will help reduce its side effects. The most efficient way is using stem cells as carriers to deliver the drugs to tumours. However, given the cytotoxicity of vincristine and other similar drugs, this solution is not optimal.

 

The microencapsulation of vincristine and other anticancer drugs solves this problem. The microencapsulated vincristine can be safely captured by stem cells and delivered to tumours through cancer migration pathways. When stem cells carrying the microencapsulated vincristine come into contact with cancer cells, vincristine is released from the microcapsules causing the cancer cells’ death.

Drug delivery to cancer cells

Loading human mesenchymal stem cells (hMSCs) with silica-coated multi-layered PSS/PAH microcapsules containing vincristine allows targeted drug delivery to tumours.

Targeted delivery of drugs

Loading human mesenchymal stem cells (hMSCs) with microcapsules

Silica-coated multi-layered PSS/PAH microcapsules (left) containing a drug (middle, in red) are engulfed by human mesenchymal stem cells (right).

Targeted delivery of drugs to tumours

References:

 

“Safe and Effective Delivery of Antitumor Drug Using Mesenchymal Stem Cells Impregnated with Submicron Carriers” 2019, Applied Materials & Interfaces (10.1021/acsami.8b22685)

 

Link: https://pubs.acs.org/doi/10.1021/acsami.8b22685

 

Mask taste and odour
Mask the taste of bitter drugs or unpleasant odour to improve palatability.
Protect active ingredients
Protect drugs from environmental conditions (moisture, oxidation, stomach pH, heat, sunlight, etc.) and interactions.
Improve bioavailability
Enhance absorption and improve the bioavailability of drugs to increase efficacy and allow optimal dosage delivery.
Increase stability
Increase the stability of drugs resulting in the shelf-life extension.
Reduce hygroscopicity and retard evaporation
Reduce drug hygroscopicity by preventing moisture, which decomposes drugs and reduces their efficacy, as well as retard the evaporation of volatile drugs.
Allow timed and targeted release
Controlled release of drugs at the right time and at the right place to improve efficacy, prolong action, and ensure optimal dosage.
Reduce dosing and gastric irritation
Reduce drug dosing and eliminate gastrointestinal irritation caused by gastric irritant drugs, thus ultimately improving patient compliance.
Allow easy handling and storage
To modify drugs’ physical characteristics for easy handling and storage. A liquid can be transformed into powder-looking capsules.
PARTNER WITH US

We are looking for partnerships with pharmaceutical companies to co-develop and co-promote our novel controlled drug delivery mechanism to bring treatment effectiveness to the next level.