BRING INNOVATION TO ANIMAL HEALTH AND FEED

Whether it’s developing innovative drug delivery mechanisms, increasing the effectiveness of nutritional supplements or decreasing dependency on medicated feeds, our microencapsulation technology can maximise production and profitability. We can help you design smart, optimal animal health and nutrition solutions.

 

We provide lab-to-market services to manufacturers of veterinary drugs, supplements and food to satisfy the demand for innovative drug delivery systems and a more comprehensive range of ingredients to improve animal health and nutrition.

INDUSTRY CHALLENGES

Manufacturers of veterinary drugs, nutritional supplements and food are constantly searching for better protection of sensitive ingredients, optimal dosage and innovative delivery systems. There are currently many challenges when it comes to animal health and nutrition.

 

Low bioavailability

 

The bioactivity of active compounds is often reduced when exposed to air, humidity, and heat. Pet food loses 30% to 50% of vitamins during processing. Similarly, poultry feeding enzymes become unstable and lose their potency when subjected to air, high temperatures, humidity, and steam during the pelleting process. The activity of phytase enzymes, used for better phosphorus absorption in poultry and pigs, is significantly reduced during hot summer months. Probiotic bacteria are also fragile requiring storage in dry conditions. Vitamin C is also very unstable, and prolonged storage of animal feed enriched with vitamin C leads to the loss of its health benefits

 

Stability and interactions issues

 

Many oils go quickly rancid, such as omega-3 fatty acid, commonly used as a supplement for animals. There are also interactions challenges. For example, the minerals encounter interaction reactions as they pass the gastrointestinal tract. Elevated levels of molybdenum, selenium, iron and sulphur interfere with copper absorption, and copper deficiency is a severe problem for cows, sheep, and goats.

 

Homogeneity

 

Drugs and supplements often face mixing challenges. In warm weather, minerals may turn into hard pellets making it difficult to combine them with feed ingredients.

More Facts

Delivery challenge due to taste and odour

 

The delivery of drugs and supplements is a common challenge due to the taste, odour or texture. The most common form of medication and supplements, the pills are often disguised with chicken, beef, or fish flavours. But even this doesn’t guarantee success. In addition, the pills usually have a low absorption rate and cause stomach irritation. Using baked snacks and kibbles as a disguise has its shortcomings as high temperature destroys heat-sensitive compounds, such as probiotics, enzymes and flavonoids. Soft-moist treats are an alternative, but moisture and acidity negate their viability.

 

To solve the problem of drug administration, companies offer “pill guns”, but it is not the ideal solution. Crushing pills into a powder can reduce the effectiveness of certain drugs. Drugs in liquid form have better absorption and cause minor stomach irritation, but the taste may be a concern. A similar taste issue is encountered with drugs in a powdered form. Also, sick animals, who eat less, may not receive the optimal drug dosage.

 

Today, some medications come as injections or implants that release slowly in the body, making daily pills redundant. There are also aerosols and transdermal gels, and patches that deliver drugs through the skin to the bloodstream. However, not all medicine is suitable for these types of applications. Also, the drugs risk being deposited on the fur, ingested by the animal or causing airway irritation.

 

Delivery challenge due to pH

 

Medicated feeds such as antibiotics used to increase growth and protect from pathogens have recently come under scrutiny due to the development of antibiotic resistance in humans. The trend shifts from the emphasis on productivity to safety. The manufacturers turn towards probiotics and enzymes, known to promote gut health, thereby lessening the use of antibiotics.

 

But probiotics are affected by packaging and storage and also by pH. The challenge is to get the living microorganisms to survive the stomach’s acidic environment to reach the intestines.

 

There are many supplements and drugs sensitive to the acidic environments of the stomach, for example, butyric acid (to improve the nutrients’ absorption), L-arginine (to repair body tissues and used for animals subjected to wounds or fractures), feed proteins and lysine hydrochloride (to increase milk production in lactating dairy cows), among others. In addition to the unpleasant odour, the challenge is to pass throughout the gastrointestinal tract to reach the hindgut of monogastric animals.

WE CAN SOLVE MANY CHALLENGES

The microencapsulation applied to animal health and nutrition can help manufacturers overcome many challenges. It protects sensitive ingredients and ensures the stability of nutrients, thus maintaining their potency through manufacturing and storage and extending their shelf life. Microencapsulation also provides resistance to mechanical damage by teeth or gizzard, prevents moisture and adverse reactions with other ingredients, improves solubility, increases nutrient absorption and bioavailability, and ensures optimal dosage.

 

Our advanced microencapsulation technology offers an opportunity to apply a novel drug delivery mechanism, which is in high demand commanding premium prices. Effectively masking taste and odour, the microcapsules can be added to any animal food making redundant the use of expensive flavourings and additives or overdosing.

 

The microencapsulation also enables the controlled release delivering the ingredients to the site, where they are most effective. The microcapsules can be designed to release at precise locations and for a specific duration. Targeted delivery of probiotics and enzymes helps prevent the colonisation of undesirable bacteria, thus reducing enteric diseases and translating into faster growth rates and decreasing the need for antibiotics.

 

In addition, in fish farming, the microencapsulated feed can replace live food required during the larvae stage and improve feed stability in the water.

Mask taste, odour and texture
Mask taste, odour and texture to improve the delivery of medication and supplements.
Protect active ingredients
Protect compounds from environmental conditions (heat, moisture, acidity, oxidation etc.) and interactions with other ingredients.
Improve bioavailability
Improve bioavailability of active compounds to increase efficacy and allow precise dosage delivery.
Increase stability
Increase the stability of active compounds resulting in the shelf-life extension.
Improve solubility and dispersibility
Increase uniformity of the final product and solve clumping issues.
Allow time and targeted release
Controlled release of active substances at the right place and time to improve efficacy, prolong action, and ensure optimal dosage.
Introduce new ingredients
Allow the introduction of new ingredients to broaden the applications and product range.
Make cost savings
Make redundant artificial flavours as masking agents and overdosing used to compensate for nutritional losses.

LET US KNOW YOUR NEEDS

 

Let us know what challenges you are facing and what you would like to improve for animal health and nutrition. We will find a solution for you. We can help you optimise food and feed to ensure better animal health and productivity. The microencapsulation will allow for product differentiation offering a competitive advantage and greater efficiency.