BRING INNOVATION TO ANIMAL HEALTH AND NUTRITION
Whether it’s developing innovative drug delivery mechanisms, increasing the health benefits of nutritional supplements or decreasing dependency on medicated feeds, our advanced microencapsulation technology is a great tool to ensure the health and well-being of animals, increase growth rates and maximise production and productivity. We can help you design smart and innovative animal health and nutrition solutions.

We provide R&D services and look for partnerships with manufacturers of veterinary drugs, nutritional supplements and animal food to satisfy the demand for innovative drug delivery systems and a more comprehensive range of ingredients to improve animal health and nutrition.

CONTROLLED-RELEASE MICROCAPSULES FOR ANIMAL HEALTH AND NUTRITION

NOVEL DRUG DELIVERY SYSTEMS FOR VETERINARY MEDICINE

Worldwide, the population of both pet and food-producing animals has been steadily growing. Manufacturers of veterinary drugs, nutritional supplements, and animal food and feed are constantly searching for improved palatability, bioavailability, and efficiency. The development of new and more efficient drug-delivery systems is becoming increasingly important to ensure animal health and well-being.

 

Our advanced microencapsulation technology offers microcapsules with a controlled release function. Our smart microcapsules enhance the therapeutic indices of drugs by protecting the encapsulated drugs from the environment and leakage, and increasing their stability and bioavailability.

 

Most importantly, our innovative drug delivery systems also make it possible for veterinarians to modify the pharmacokinetic parameters of the drugs and finely tune the drug release rate over periods of hours to months to improve drug efficacy, prolong action, and optimise dosage. Our targeted drug release function is a reliable means to maximise therapeutic efficacy by delivering drugs to the target site (specific tissues, organs or cells) to achieve a desired concentration level, reduce dosage and minimise toxic effects on healthy tissues. Our timed-release function provides the convenience of dosing animals once rather than with repeated administration.

Controlled-release microencapsulation for veterinary applications

WE OFFER A BETTER ALTERNATIVE TO LIPOSOMES FOR VETERINARY MEDICINE AND NUTRITION

Today, liposomes are among the most effective and widespread delivery systems of therapeutic substances in animals. However, the use of liposomes is limited by their poor chemical and physical stability, leakage and fusion of encapsulated active substances, poor control over drug release, low loading capacity and high manufacturing costs. Also, the choice of active substances is limited. Another popular encapsulation system is the emulsification of compounds into microdroplets. Similarly to liposomes, emulsion droplets are unstable and lack controlled release function, enabling only passive elution. The emulsification process also limits the choice of active substances.

 

Our smart microcapsules are a better alternative to liposomes. In contrast to liposomes, our microcapsules are highly stable. Our technology creates a physical barrier isolating and protecting active substances against degrading factors, such as heat, sunlight, moisture, oxidation, or incompatibility and interactions with other ingredients. Effectively sealing the content, our microcapsules are stable, invisible, tasteless and odourless. They are biocompatible and biodegradable, have high loading capacity, are versatile, applicable for the incorporation of any active substances, from small to large, both hydrophilic and hydrophobic and are suitable for large-scale, cost-effective production. Most importantly, our programmed-shell microcapsules have a controlled release mechanism.

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    Highly stable.

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    The shell isolates and protects active ingredients against degrading factors, incompatibility and interactions with other ingredients.

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    Possess the functions of controlled and targeted delivery of active substances.

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    Versatile, applicable for the incorporation of any active substances, both hydrophilic and hydrophobic.

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    Able to hold massive payloads.

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    Suitable for large-scale, cost-effective production.

SMART CONTROLLED-RELEASE MICROCAPSULES FOR ANIMAL HEALTH

The most important advantage of our advanced microencapsulation technology and what makes us unique is the controlled drug delivery function. Our technology provides a versatile tool for the controlled and targeted delivery of active substances for better outcomes. It allows modulation of the release profile (time and site) and pharmacokinetics parameters without changes in the pharmacological properties of the therapeutic agents. Possessing unique microencapsulation know-how, we can precisely programme the release time of active substances, the location and the duration of the release, achieving efficacy at an entirely different level. We deliver active compounds to the target site, where they are most effective. And all this at a low price. Production costs are mainly determined by the price of polymers and encapsulated active substances, representing a fraction of the final price.

 

Our technology offers therapeutically highly efficient, low-risk and cost-effective drug delivery systems. The safer and more effective pharmacotherapy leads to reduced toxicity associated with lower drug doses, increasing safety for the consumers of livestock products. Our technology also has great potential to restore the use of old drugs by modifying their biodistribution, improving bioavailability, and reducing toxicity.

 

Our smart microcapsules can be delivered through the intramuscular, subcutaneous, intravenous, ocular, or intranasal route. Our technology can be applied in veterinary medicine to improve the delivery of analgesic, antimicrobial, antifungal, anticancer, and antiviral drugs and substances in companion and productive animals. Besides veterinary medicine, it can be used for feed additives as well as in transfection technologies and in the cryopreservation of stallion or bull semen.

  • PROLONGED RELEASE

    Our microcapsules provide sustained and prolonged drug release over periods of hours to months.

  • RELEASE WITH THE REQUIRED KINETICS

    Our microcapsules provide drug release with a desired rate and dosage.

  • TIMED RELEASE

    We can programme the microcapsule shells to release drugs at a desired time.

  • TRIGGERED RELEASE

    We introduce the release-on-demand mechanism. The microcapsule opening can be triggered by environmental changes (pH, salinity, solvent polarity, temperature), external stimuli (ultrasound, NIR laser) or a cancer-specific environment.

     

NOVEL HIGHLY EFFICIENT DRUG DELIVERY SYSTEMS FOR VETERINARY MEDICINE

For better health and well-being of all animals.

WIDE CHOICE OF DRUGS

 

We can encapsulate any molecule, from small (down to microelements) to large (DNA, RNA, proteins). Our microcapsules can hold multiple drugs, making them multifunctional.

 

 

 

WIDE CHOICE OF SHELL MATERIAL

 

We can choose from a wide range of FDA-approved biocompatible and biodegradable non-toxic polymers, synthetic or natural. We can make shells mono- or multi-layered.

 

 

HIGH STABILITY

 

Unlike liposomes and emulsion droplets, our polyelectrolyte microcapsules are highly stable.

 

 

 

 

 

HIGH LOADING CAPACITY

 

Our microcapsules can hold high volumes of active substances (active substances: 75-80%, polymers: 20-25%).

 

 

 

 

 

HIGH STABILITY

Unlike liposomes and emulsions, our microcapsules are highly stable, creating a real barrier between active substances and the environment. Many active substances are sensitive to degradation when exposed to the acidic environment of the GIT. Our microcapsules show remarkable stability in the acidic pH, increasing bioavailability and overall efficacy.

HIGH STABILITY COMPARED TO LIPOSOMES

 

Today, the most common encapsulation systems are represented by liposomes and the emulsification into microdroplets. However, their significant drawback is poor stability. In contrast to liposomes and emulsions, our polyelectrolyte microcapsules are far more stable creating a real physical barrier between encapsulated substance and a surrounding environment.

 

 

 

 


REMARKABLE STABILITY UNDER ACIDIC PH

 

The current trend shifts from the emphasis on productivity to safety, and the manufacturers of medicated feeds, which include antibiotics, turn more to probiotics and enzymes. The challenge with probiotics is to get the living microorganisms to survive the stomach’s acidic environment to reach the intestines or the hindgut of monogastric animals. In addition to probiotics, there are other supplements sensitive to the acidic environments of the stomach, such as L-arginine, feed proteins and lysine hydrochloride. The challenge is to pass through the gastrointestinal tract. We solve this problem. Our microcapsules remain stable under acidic pH < 6 for more than 9 hours and reach the intestines or the hindgut, where they are absorbed and delivered to the target tissues and organs.


TIMED DRUG RELEASE

Possessing unique microencapsulation capabilities, we can precisely programme the release time of active compounds, achieving efficacy at an entirely different level. While slow-release formats are not new on the market, we move one step forward by introducing a timed-release function, a new way to deliver active substances. Our smart microcapsules can be programmed to open and release active compounds at a desired time and with the required kinetics.

REDUCE THE NUMBER OF ADMINISTERED DOSES

 

In the pet pharmaceutical market, the convenience of drug administration for pet owners determines the success of pharmacotherapy. In the case of food-producing animals, decreasing livestock handling reduces animal stress and production costs.

 

Our advanced microencapsulation technology helps redesign formulations to replace multiple doses with only one daily intake. We can programme the opening of microcapsules and the release of active substances at a specific time. Our advanced microencapsulation technology provides the convenience of dosing large groups of animals once with a timed-release dosage form rather than with repeated administration involving greater effort at animal management.


Timed-release microcapsules for animal health and nutrition

TARGETED DRUG DELIVERY

Traditional cancer chemotherapy is associated with serious toxicity and side effects due to the lack of a specific selection of tumour cells, which restricts its curative effect. Precisely targeting a drug to a specific organ or tissue and controlling the rate of drug delivery to the target site reduces toxicity and improves cellular uptake and clinical outcomes.

DRUG DELIVERY TO CANCER CELLS

 

Cancer therapy involves the use of chemotherapeutic drugs which encounter significant barriers to the successful elimination of cancer cells. These barriers include a lack of selectivity for cancer cells, low bioavailability at tumour sites, larger volumes of distribution, and toxicity to normal tissues. Our targeted drug delivery system helps overcome these barriers. In veterinary medicine, our technology enables the targeted delivery of antitumor drugs to reduce or avoid the side effects of conventional chemotherapy and decrease toxicity.

 

Our smart microcapsules are capable of detecting and destroying cancer cells, achieving site-specific targeting. Our technology enables the drug release triggered by a cancer-specific environment. Due to their rapid and uncontrolled proliferation, cancer cells are characterised by elevated levels of reduced glutathione, which can serve as a trigger for microcapsule opening and drug release. We designed smart microcapsules that open and release drugs directly into cancer cells without affecting healthy stem cells.


Targeted drug delivery to cancer cells for veterinary medicine

TARGETED DRUG DELIVERY USING MAGNETIC FIELD

 

Our technology enables the functionalisation of microcapsules with nanoparticles, making possible the fabrication of magnetically targetable microcapsules by incorporating Fe3O4 NPs into the shell. These magnetically responsive microcapsules can be directed towards a specific organ or tissue in the animal body by using an external magnetic field. Microcapsules carrying a drug accumulate in the target site, and the drug is released from the microcapsules in a controlled manner.

 

Magnetic targeting is a promising delivery system with remote navigation by the magnetic field. It has great potential in the treatment of malign tumours as it opens immense opportunities for targeted and controlled drug release. Our magnetic targeting system can also be used for more efficient delivery of genetic material (DNA, RNA), proteins, and other biologically active material into cells.


Targeted drug delivery using a magnetic field for veterinary medicine

TRIGGERED DRUG RELEASE

Our polyelectrolyte multi-layered composite microcapsules provide a very versatile tool to create smart drug delivery systems sensitive to chemical, physical, or mechanical factors. Using our advanced microencapsulation, we achieve a broad range of controlled-release scenarios. Our technology enables drug release triggered by physiological stimuli, such as pH, ionic strength, and temperature or drug release triggered by remote stimuli, such as ultrasound and near-infrared (NIR) laser light.

CHANGES IN THE ENVIRONMENT

 

Drug release can be triggered by changes in pH, ionic strength (salinity), solvent polarity, and temperature.

 

 

CANCER-SPECIFIC ENVIRONMENT

 

Drug release can be triggered by a cancer-specific environment. We designed smart microcapsules that open and release drugs in cancer cells, leaving healthy stem cells intact.

EXTERNAL STIMULI

 

Drug release can be triggered by external stimuli, such as ultrasound or near-infrared (NIR) laser light.

 

 

Triggered drug release for veterinary medicine
Mask taste, odour and texture
Mask taste, odour and texture to improve the delivery of medication and nutritional supplements.
Protect active substances
Protect compounds from environmental conditions (heat, moisture, acidity, oxidation, etc.) and interactions with other ingredients.
Improve bioavailability
Improve the bioavailability of active compounds to increase efficacy and allow for precise dosage delivery.
Increase stability
Increase the stability of active compounds, resulting in the shelf-life extension.
Reduce hygroscopicity, improve solubility and dispersibility
Reduce the hygroscopicity and increase the solubility of the ingredients, resulting in improved bioavailability.
Controlled and targeted release
Controlled release of active substances at the right place and at the right time to improve efficacy, prolong action, and optimise dosage.
Triggered release
Introduce release on-demand mechanism when drug release is triggered by pH, ultrasound, NIR laser light and other stimuli.
Make cost savings
Make redundant artificial flavours as masking agents and overdosing used to compensate for nutritional losses.
PARTNER WITH US

We seek partnerships with manufacturers of veterinary drugs, nutritional supplements and animal food to bring our innovations to the market. Let us know what challenges you are facing and what you would like to improve for animal health and well-being. We will find a solution for you and will help you design advanced, tailor-made and fully customisable microencapsulation solutions.