ADVANCED MICROENCAPSULATION WITH CONTROLLED AND TARGETED RELEASE
We developed cutting-edge microencapsulation technology to produce programmed-shell microcapsules with controlled and targeted release functions. We design tailor-made, advanced drug delivery systems and create smart microencapsulation solutions for various industrial sectors, from pharmaceuticals and nutraceuticals to functional food and cosmetic ingredients.
Microcapsules are an imperceptible solution to noticeable problems.

Microencapsulation is a complex technique that involves incorporating active compounds – liquids, solids or gases – in tiny protective spheres (microcapsules) having a diameter as small as Ø 0.5 to 10 µm. The microcapsules look like powder to the naked eye. The coating (shell), which is thinner than the width of human hair, creates a barrier, isolating and protecting active compounds from the external environment.

 

We offer more than just simple microencapsulation. We pioneered programmed-shell microcapsules with controlled and targeted drug-release functions. We programme the microcapsule shells to enable a release on demand – release at the right place, in the right dosage, at the right time, and under certain conditions to address specific needs. Based on polyelectrolyte multi-layered composite microcapsules invented by our CSO, Professor Gleb Sukhorukov, our advanced microencapsulation technology is a game-changer.

Advanced microencapsulation with controlled release
IT’S NOT JUST ANOTHER MICROENCAPSULATION

Different microencapsulation techniques are currently available on the market. They include emulsion spray-drying, microemulsification, liposomal and microfluidic microencapsulation. However, the widespread emulsion spray-drying and microemulsification techniques are technologically limited solutions, producing emulsion microdroplets without a shell, which aren’t technically microcapsules. The absence of a distinctive external wall, or shell, makes the controlled release impossible. The emulsification process also limits the choice of active substances for microencapsulation.

 

Liposomes and microfluidic solutions are more advanced options. While liposomes have been increasingly popular over the last couple of decades as nanocarriers for drug delivery, they have several limitations. Their major drawbacks include their limited stability, both physical and chemical, high production costs, leakage and fusion of encapsulated drugs/molecules and low solubility. Also, the choice of active substances for microencapsulation is limited. The more advanced microfluidic technology has attracted growing interest in recent years. However, despite its potential, there is still a step away from laboratory research to large-scale industrial production. Microfluidics remains a high-cost and low-yield technique, limiting it to research purposes.

SMART MICROCAPSULE
Programmed-shell microcapsule for novel drug delivery systems
LIPOSOME
Liposomes for drug delivery
EMULSION
Emulsions for drug delivery
Controlled drug release
Limited or no control over drug release

ADVANCED MICROENCAPSULATION TECHNOLOGY

Our coaxial electrospray technology combines the best of the available microencapsulation techniques. It is as advanced as microfluidics, but with regard to production volumes and costs, it is in the same range as spray-drying and microemulsification. Unlike microemulsions that are widely used for prolonged drug release, our polyelectrolyte multi-layered composite microcapsules have a shell that creates a physical barrier isolating the encapsulated compounds from the environment. We offer true core-shell structures.

PROGRAMMED-SHELL MICROCAPSULES WITH CONTROLLED AND TARGETED RELEASE FUNCTIONS

Compared to the existing microencapsulation techniques, our programmed-shell microcapsules offer some unique properties and diversity of controlled release regimes. The shells could be readily modified to incorporate various additive layers, such as silica, nanoparticles, and lipids, to make microcapsules responsive to remote stimuli, such as ultrasound, near-infrared laser light, magnetic field, and others.

WE ARE EXPERTS IN MICROENCAPSULATION

INCAPTEK’s unique microencapsulation technology is based on more than 25 years of ongoing research. Possessing an unmatched expertise in microencapsulation, we design advanced, tailor-made and fully customisable microencapsulation solutions.

Isolation and protection

Our microcapsules isolate and protect active substances from the environment and prevent leakage. Our microcapsules survive the stomach's acidity.

High stability

The shells are stabilised by electrostatic forces, making our polyelectrolyte microcapsules inherently more stable than liposomes.

Wide range of active substances

We encapsulate any drugs regardless of their molecular weight and solubility, from small (down to microelements) to large (DNA, RNA, proteins) and even microorganisms.

“A la carte” drug release

Our technology provides unique functionality in the form of controlled and targeted release functions with a broad range of controlled-release scenarios (release triggered by various stimuli).

Wide range of polymers

Polyelectrolyte shells can be designed from a variety of relatively inexpensive, biocompatible and biodegradable FDA-approved polymers, natural or synthetic.

High loading capacity

Our microcapsules can hold high volumes of active substances (active substances: 75-80%, polymers: 20-25%). The shells can be mono- or multi-layered.

Uniform microcapsules

Our technology allows full control over the size of the microcapsules with Swiss precision to ensure that they are all uniform.

Scalable, cost-effective production

Production costs are mainly determined by the price of polymers and encapsulated compounds, representing a fraction of the final price.

WE INTRODUCE CONTROLLED-RELEASE MICROCAPSULES

We introduce smart microcapsules offering a unique functionality – controlled and targeted delivery of active substances. Our advanced microencapsulation technology produces programmed-shell microcapsules with a complex shell design that can open and release active substances according to predefined scenarios. Such competitive advantages are the result of our R&D team’s long-standing experience and leading position in scientific research.

 

We ensure controlled release by varying polymers’ composition, density, and shell thickness. The selection of the appropriate shell material depends on the objectives, specific requirements and the final application of the product. We also take into consideration the microparticle size, properties of active compounds, environmental conditions, the required release mechanism and stability.

PROLONGED RELEASE

We offer a sustained and prolonged release of active compounds.

RELEASE WITH A REQUIRED KINETICS

Our microcapsules provide release with a desired rate and dosage.

TIMED RELEASE

We programme the microcapsule shells to release active substances at a specific time of the day.

TRIGGERED RELEASE

Microcapsule openings can be triggered by environmental changes or external stimuli.

Timed release

Sustained-release formulations are gaining popularity. But the release at a defined point in time remains a very complex task. None of the existing technologies can do that. Our technology can. We achieve the opening of microcapsules and the release of active substances at a specific time of the day. Our technology allows patients to take drugs or dietary supplements only once a day instead of several intakes.

Timed release microcapsules

Triggered release

We offer a release on-demand mechanism and a diversity of controlled release regimes. The microcapsule shells are modified to incorporate various additive layers, such as silica, nanoparticles, and lipids, to make microcapsules responsive to pH, a cancer-specific environment or remote stimuli, such as ultrasound, near-infrared (NIR) laser light, and magnetic field.

CHANGES IN THE ENVIRONMENT

Release triggered by changes in the environment, such as pH, ionic strength (salinity), solvent polarity, and temperature.

CANCER-SPECIFIC ENVIRONMENT

Release triggered by a cancer-specific environment. We designed smart microcapsules that open and release drugs in cancer cells, leaving healthy stem cells intact.

EXTERNAL STIMULI

Release triggered by external stimuli, such as ultrasound or near-infrared (NIR) laser light.

Targeted release

Sustained-release formulations are gaining popularity. But the release at a defined point in time remains a very complex task. None of the existing technologies can do that. Our technology can. We achieve the opening of microcapsules and the release of active substances at a specific time of the day. Our technology allows patients to take drugs or dietary supplements only once a day instead of several intakes.

DRUG DELIVERY TO CANCER CELLS

Our smart microcapsules can release drugs directly into cancer cells without affecting healthy stem cells.

DRUG DELIVERY TO TUMOURS USING MSCs

Our technology enables targeted drug delivery to tumours using human mesenchymal stem cells containing microcapsules with anticancer drugs.

DELIVERY OF GENETIC MATERIAL INTO CELLS

Our microcapsules provide more efficient non-viral delivery of genetic material (DNA, RNA) to cells, increasing the efficacy of CAR T-cell and gene therapies.

TARGETED DRUG DELIVERY USING MAGNETS

Using magnetically responsive microcapsules, we can direct and release drugs at a specific site of the body of the body.

COAXIAL ELECTROSPRAY TECHNOLOGY

Our patented coaxial electrospray technology produces micron- and submicron structures of a given geometry (spheres, fibres). To produce microcapsules, an active substance enters through the inner tube, and a shell through the outer tube. Both are combined on the exit, resulting in the controlled process of microencapsulation. This technique enables us to encapsulate a wide range of active substances and achieve the required properties of the final product.

 

The production capacity of one industrial unit ranges from several kilos to several tons of microcapsules per month.

Polyelectrolyte multi-layered composite microcapsules
Nanofibres
Coaxial electrospray technology for microencapsulation
Mask taste, odour, colour, and texture
Mask taste, odour, colour and texture to improve palatability and product attractiveness.
Protect active ingredients
Protect active compounds from environmental conditions (moisture, oxidation, stomach pH, heat, sunlight, etc.) and interactions with other ingredients.
Improve bioavailability
Improve the bioavailability of active compounds to increase efficacy and allow optimal dosage delivery.
Increase stability
Increase the stability of active compounds resulting in the shelf-life extension.
Improve solubility and dispersibility
Increase solubility of the ingredients, especially of powdered forms, resulting in improved bioavailability.
Allow timed and targeted release
Controlled release of active substances at the right time and at the right place to improve efficacy, prolong action, and ensure optimal dosage.
Introduce new ingredients
Allow the introduction of new ingredients to broaden the applications and product range.
Make cost savings
Make redundant artificial flavourings, sweeteners, colourings, and other masking agents, as well as overdosing used to compensate for nutritional losses.