Within a short time, catheters, stents and implants became the default interventional strategy, and drug-eluting coatings have revolutionised treatments. Representing a new and effective approach to local drug delivery, they can solve a variety of problems. However, the unsustainable and uncontrolled drug release is a challenge. Using our technology, drugs can be released in a controlled manner, greatly improving therapeutic effectiveness.
We provide lab-to-market services to medical device producers and pharmaceutical companies to satisfy the demand for innovative and efficient treatments.
Small drug molecules leak too fast from the drug-eluting coatings, reducing their effectiveness over time and requiring higher doses of medication. As a result, this increases the risks of side effects and reduces the effectiveness of treatment.
Our microcontainer film technology solves this problem. Our biocompatible patterned microcontainer films can be used as high-performance coatings for catheters, stents, implants, and transdermal patches to achieve the controlled and timed release of active substances, thus increasing treatment effectiveness.
The patterned microcontainer films can be designed to achieve controlled and timely drug release on demand ensuring local, accurate and effective drug dosage:
Microcontainer films can be made from FDA-approved polymers – synthetic biocompatible and biodegradable polymers (PCL, PLA, PLGA, etc.) or natural (albumin, alginate, agar-agar, gelatin, etc.) – and filled with almost any active substance (cargo-shell ratio up to 10:1). The proper choice of polymers can improve the bioavailability of encapsulated substances, which is critical for many medical applications.
Microcontainers can be filled with a wide range of drugs regardless of molecular weight and solubility.
Microcontainers’ shape, size and thickness are adjustable to meet the required properties.
Our patterned microcontainer film is a biopolymer film with microcontainers, looking like micro-air bubbles, which contain a drug. It’s like bubble wrap only at the micro-level.
Figure 1. Patterned microcontainer film coatings
(a-c) Coatings made of (a) PCL (polycaprolactone), (b) PLA (polylactic acid), and (c) PLGA (Poly-D, L-lactide-co-glycolide).
(d) Patterned microcontainer film structure (left) and a single microcontainer filled with a substance (methylprednisolone sodium succinate) (right).
Figure 2. 3D-image of patterned microcontainer film coatings
Confocal images of PCL, PLA, and PLGA patterned microcontainer film coatings filled with fluorescence (FITC-dextran).
Figure 3. Patterned microcontainer film coatings for drug-eluting medical stents
a) Scanning electron microscopy images of the stents coated with patterned microcontainer films made of PCL, PLA, and PLGA.
b) Stent with a patterned microcontainer film coating.
Figure 4. Microcontainers’ shape, size and thickness can vary
Our patterned microcontainer films can be programmed to open and release drugs on demand triggered by low-intensity ultrasound or other external stimuli.
Figure 5. Ultrasound-triggered drug release from the patterned microcontainer film
The microcontainer film filled with a drug is placed next to the blood vessel, and, whenever needed, the drug is released by directing ultrasound to the body.
The release of anti-inflammatory drugs (prednisolone) is triggered by low-intensity ultrasound. In total: 25 surgical procedures with positive feedback from clinicians (reduced inflammation and stenosis).
Figure 6. Ultrasound-triggered drug release from urethral catheter coated with the patterned microcontainer film
Prednisolone-loaded patterned microcontainer films before and after ultrasound treatment.
The prolonged delivery of anti-inflammatory drugs (prednisolone). Total: 8 surgical procedures with positive feedback from clinicians (minimised restenosis).
Figure 7. Biliary stent coated with the patterned microcontainer film
Coatings for bone implants for the prolonged drug release (cefazolin) for prevention of bacterial infection. 1 cancer patient was successfully treated (no signs of infection since January 2022).
Figure 8. Bone implant coated with the patterned microcontainer film
Next in the pipeline – the coatings for hernia meshes for the prolonged drug delivery (rebamipide) to prevent the risk of post-surgery implant-associated infections and the damaging effects of NSAIDs.
Figure 9. Hernia meshes
Next in the pipeline – the coatings for ventricular drainage and cranial meshes for the prolonged release of antibiotics (vancomycin and meropenem) to prevent implant-associated bacterial infection after brain surgery.
Figure 10. External ventricular drainage (EVD) and cranial meshes
Patents and patent applications:
Overall, our team has over 400 scientific publications on patterned microcontainer films and microencapsulation technologies.
Let us know what challenges you are facing and what you would like to improve. We will find a solution for you. We can help you combine the benefits of multiple nutrients into a single ingredient source in order to create superior product performance and reduce ingredient losses.