TRANSFORM THE FIELD OF CATHETERS, STENTS AND IMPLANTS INTERVENTIONS

Within a short time, catheters, stents and implants became the default interventional strategy, and drug-eluting coatings have revolutionised treatments. Representing a new and effective approach to local drug delivery, they can solve a variety of problems. However, the unsustainable and uncontrolled drug release is a challenge. Using our technology, drugs can be released in a controlled manner, greatly improving therapeutic effectiveness.

 

We provide lab-to-market services to medical device producers and pharmaceutical companies to satisfy the demand for innovative and efficient treatments.

MICROCONTAINER FILMS WITH THE CONTROLLED DRUG RELEASE FOR DRUG-ELUTING COATINGS

Small drug molecules leak too fast from the drug-eluting coatings, reducing their effectiveness over time and requiring higher doses of medication. As a result, this increases the risks of side effects and reduces the effectiveness of treatment.

 

Our microcontainer film technology solves this problem. Our biocompatible patterned microcontainer films can be used as high-performance coatings for catheters, stents, implants, and transdermal patches to achieve the controlled and timed release of active substances, thus increasing treatment effectiveness.

 

Controlled and timed release function

 

The patterned microcontainer films can be designed to achieve controlled and timely drug release on demand ensuring local, accurate and effective drug dosage:

 

  • Prolonged drug release, thereby reducing side effects for patients
  • Timed drug release (opening of microcontainers at a specific time)
  • Drug release triggered by ultrasound, light, pH, temperature, etc.

 

Biocompatible and biodegradable polymers

 

Microcontainer films can be made from FDA-approved polymers – synthetic biocompatible and biodegradable polymers (PCL, PLA, PLGA, etc.) or natural (albumin, alginate, agar-agar, gelatin, etc.) – and filled with almost any active substance (cargo-shell ratio up to 10:1). The proper choice of polymers can improve the bioavailability of encapsulated substances, which is critical for many medical applications.

 

Large choice of drugs

 

Microcontainers can be filled with a wide range of drugs regardless of molecular weight and solubility.

 

Flexible shape, size and thickness

 

Microcontainers’ shape, size and thickness are adjustable to meet the required properties.

Our patterned microcontainer film is a biopolymer film with microcontainers, looking like micro-air bubbles, which contain a drug. It’s like bubble wrap only at the micro-level.

Figure 1. Patterned microcontainer film coatings

(a-c) Coatings made of (a) PCL (polycaprolactone), (b) PLA (polylactic acid), and (c) PLGA (Poly-D, L-lactide-co-glycolide).
(d) Patterned microcontainer film structure (left) and a single microcontainer filled with a substance (methylprednisolone sodium succinate) (right).

Patterned microcontainer film as a novel drug-eluting coating

Figure 2. 3D-image of patterned microcontainer film coatings

Confocal images of PCL, PLA, and PLGA patterned microcontainer film coatings filled with fluorescence (FITC-dextran).

Patterned microcontainer film, a novel drug-eluting coating, filled with fluorescence

Figure 3. Patterned microcontainer film coatings for drug-eluting medical stents

a) Scanning electron microscopy images of the stents coated with patterned microcontainer films made of PCL, PLA, and PLGA.
b) Stent with a patterned microcontainer film coating.

Patterned microcontainer film as a novel drug-eluting coating for stents
Patterned microcontainer film as a novel drug-eluting coating for stents

Figure 4. Microcontainers’ shape, size and thickness can vary

DRUG RELEASE BY ULTRASOUND

Our patterned microcontainer films can be programmed to open and release drugs on demand triggered by low-intensity ultrasound or other external stimuli.

Figure 5. Ultrasound-triggered drug release from the patterned microcontainer film

The microcontainer film filled with a drug is placed next to the blood vessel, and, whenever needed, the drug is released by directing ultrasound to the body.

Ultrasound-triggered drug delivery
PILOT CLINICAL TRIALS
Drug-eluting coatings for urethral catheters – drug release by ultrasound

The release of anti-inflammatory drugs (prednisolone) is triggered by low-intensity ultrasound. In total: 25 surgical procedures with positive feedback from clinicians (reduced inflammation and stenosis).

Figure 6. Ultrasound-triggered drug release from urethral catheter coated with the patterned microcontainer film

Prednisolone-loaded patterned microcontainer films before and after ultrasound treatment.

Ultrasound-triggered drug delivery
Drug-eluting coatings for biliary and pancreatic stents – prolonged drug release

The prolonged delivery of anti-inflammatory drugs (prednisolone). Total: 8 surgical procedures with positive feedback from clinicians (minimised restenosis).

Figure 7. Biliary stent coated with the patterned microcontainer film

Controlled drug release from drug-eluting stents
Drug-eluting coatings for bone implants – prolonged drug release

Coatings for bone implants for the prolonged drug release (cefazolin) for prevention of bacterial infection. 1 cancer patient was successfully treated (no signs of infection since January 2022).

Figure 8. Bone implant coated with the patterned microcontainer film

Drug-eluting coatings for hernia meshes – prolonged drug release

Next in the pipeline – the coatings for hernia meshes for the prolonged drug delivery (rebamipide) to prevent the risk of post-surgery implant-associated infections and the damaging effects of NSAIDs.

Figure 9. Hernia meshes

Drug-eluting coatings for ventricular drainage and cranial meshes – prolonged drug release

Next in the pipeline – the coatings for ventricular drainage and cranial meshes for the prolonged release of antibiotics (vancomycin and meropenem) to prevent implant-associated bacterial infection after brain surgery.

Figure 10. External ventricular drainage (EVD) and cranial meshes

References:

 

“Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies” 2021, Pharmaceutics

“Microchamber arrays made of biodegradable polymers for enzymatic release of small hydrophilic cargos” 2020, Soft Matter

“Polylactic acid-based patterned matrixes for site-specific delivery of neuropeptides on-demand: functional NGF effects on human neuronal cells” 2020, Frontiers in bioengineering and biotechnology

“Stimuli-Responsive Microarray Films for Real-Time Sensing of Surrounding Media, Temperature, and Solution Properties via Diffraction Patterns” 2020, ACS Applied Materials & Interfaces

“Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings” 2019, European Polymer Journal

“The effect of a controlled release of Epinephrine hydrochloride from PLGA microchamber array: in vivo studies” 2018, ACS Applied Materials & Interfaces

“Polyelectrolyte multilayer microchamber-arrays for in-situ cargo release: Low frequency vs. medical frequency range ultrasound” 2018, Colloids and Surfaces A

“In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays” 2018, Journal of Controlled Release

“Polylactic acid sealed polyelectrolyte multilayer microchambers for entrapment of salts and small hydrophilic molecules precipitates” 2017, ACS Applied Materials & Interfaces

“Polylactic acid nano-and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound” 2017, Nanoscale

“Individually Addressable Patterned Multilayer Microchambers for Site‐Specific Release‐On‐Demand” 2013, Macromolecular rapid communications

 

Patents and patent applications:

 

“Photosensitive capsules and cosmetic and pharmaceutical use thereof” 2021, US10945963B2

“Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells” 2020, US20200375914A1

“Core-shell composite material” 2018, US20180344650A1

“Array of microcapsules for controlled loading of macromolecules, nanoparticles and other nanoscale items and a method of fabricating it” 2013, US8343773B2

 

Overall, our team has over 400 scientific publications on patterned microcontainer films and microencapsulation technologies.

LET US KNOW YOUR NEEDS

 

Let us know what challenges you are facing and what you would like to improve. We will find a solution for you. We can help you combine the benefits of multiple nutrients into a single ingredient source in order to create superior product performance and reduce ingredient losses.